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Indeed, previous in vitro studies demonstrated that isoproterenol, a non-subtype-selective -AR agonist, could promote glucose uptake in the L6 muscle cell line in an mTORC2-dependent manner 18 , raising the possibility that mTORC2 may play a role in mediating the beneficial metabolic effects of SKM 2 -AR stimulation

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However, HLA testing is particularly valuable for certain drugs like abacavir, as individuals with the HLA-B*5701 allele have a very high risk of developing severe hypersensitivity reactions, including DILI [82]

(2012) 303:G589599