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Most peptides are rapidly degraded by digestive enzymes if taken orally

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It is an analogue of the ACTH(4-10) fragment of adrenocorticotropic hormone, specifically derived from the ACTH(4-7) core sequence (Met-Glu-His-Phe) the minimal active fragment responsible for the cognitive and neuroprotective activity of ACTH with a C-terminal Pro-Gly-Pro (PGP) tripeptide extension appended to enhance metabolic stability and, as subsequent research has revealed, to contribute independent pharmacological activity of its own

Media replacement schedules vary based on system design and operational parameters but are typically required every 25 years for most BAC systems

Lin X, Zamora PO, Albright S, Glass JD, Pea LA