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Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks

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Topical epidermal growth factor (EGF) serum, topical mometasone fractional Er: YAG laser, 5% picolinamide cream, and 5% methimazole cream have low-to-very low or insufficient evidence (grades C-D).[34,62,114,115,116,117,118,119,120,121,122,123,124,125] The details of these agents are summarized in the supplementary Table 2 (249.3KB, pdf)