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The protein similarity somehow reflects the gene arrangement since PtGSTF1 and PtGSTF2 genes are present in tandem on chromosome 2, PtGSTF4 , 5, 6, and 7 genes cluster on the scaffold 36, whereas PtGSTF3 and PtGSTF8 are found at isolated loci on the chromosomes 14 and 17, respectively

An enormous challenge in such animal models is to establish the relevance of the mechanisms elucidated to OCD in humans

Such is the case with the combined use of agents that stimulate protein synthesis, such as short-term use of glucocorticoids or omega-3 fatty acids, 52 and agents that prevent catabolism, specifically thalidomide, which downregulates the ubiquitin-proteasome proteolysis pathway involved in protein degradation

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