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2020;44(3): e13140

doi: 10.1016/S0140-6736(87)91361-4 36 HirschECBrandelJ-PGallePJavoy-AgidFAgidY

J.YoonJ

C.et al (1995)

Specifically, they demonstrated that lactic acid can modify histones, thus influencing gene transcription, and, for the first time, identified lactic acid as an epigenetic regulator. Subsequent studies revealed widespread lactylation across various cell types, involving both histone and nonhistone lactylation, implicating this modification in signal transduction, metabolic regulation, and cell fate determination