Remarkably, immune checkpoint inhibitor (ICI) treatment targeting the PD-1/PD-L1 pathway is highly effective for metastatic mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) CRC 6
SHMT: Serine hydroxymethyltransferase
Contraindications: Mechanical obstruction: should not be given to patients having any form of mechanical obstruction in the GI tract or bladder Compromised GI or Bladder Wall Integrity : should not be given to patients where the integrity of the gastrointestinal or bladder wall is in question Hypersensitivity to bethanechol chloride tablets, Hyperthyroidism Peptic ulcer Latent or active bronchial asthma, Pronounced bradycardia or hypotension Vasomotor instability Coronary artery disease Epilepsy Parkinsonism Side Effects: Early signs of overdosage are abdominal discomfort, blurred vision, salivation, flushing of the skin (hot feeling), sweating, nausea and vomiting ( SLUDE-like symptoms ) 2) , bronchoconstriction, increased stomach acid secretion, hypotension
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When combined with anti-CTLA-4 therapy, this remodeling approach effectively suppressed tumor growth in CRC models rich in CAFs (75)
