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40 The Nrf2/ARE pathway, by inducing antioxidant and anti-inflammatory responses, contributes significantly to the alleviation of oxidative stress and inflammation in the gut, thus playing a protective role in conditions like IBD

Studies suggest that pharmacological activation of Akt-Nrf2 signalingthrough natural compounds like polydatin or ginsenosidescan ameliorate SCIRI by enhancing antioxidant capacity, suppressing NF-B-mediated neuroinflammation, and preserving mitochondrial function

Manage Stress and Exercise: Mindfulness and regular physical activity help manage stress-related depletion and enhance antioxidant defenses

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