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TCEP tris(2 -carboxyethyl) phosphine DTT dithiothreitol L is a cleavable linker moiety bonded to said antibody, preferably via a thiol residue, D is a cytotoxic drug moiety bonded to L, p is from 1 to 8, preferably from 6 to 8, and more preferably p is 8

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In light of evidence from animal models that brain GSH concentrations peak in the morning, 46 the single study visit was scheduled at 0700 hours for each participant in an attempt to control for circadian fluctuations