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This notion is mainly based on the extensive inter-individual variations observed in the efficacy of standard protocols used in the treatment of diseases, such as depression, cancer, hypertension, epilepsy and diabetes, as well as in the drug-related adverse reactions and toxicity outcomes ( Drug Metabolism Every drug entering the body is recognized as a threat of homeostasis and the detoxifying systems are activated ( During drug metabolism of Phase I, cytochrome P450s (CYPs), flavin-containing monoxygenases (FMO) and epoxide hydrolases (EH) are the main families of enzymes that catalyze the biotransformation of xenobiotics including drugs

Additionally, environmental factors like geography, urbanization, and diet play important roles, among which urbanization shows the strongest correlation with reduced fungal diversity, followed by geographic, dietary, and ethnic factors 12,29