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However, the de-pigmenting effects at the presence of 0.1, 1 and 10 mM of -arbutin are individually much lower than that of 50 M T1

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However, PARL inhibition by PARL-IN-1 reveals alternative PINK1 trafficking pathways, leading to the accumulation of MPP-cleaved PINK1 in the mitochondria and partial degradation of PINK1 by the IMM metalloprotease OMA1

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Clinical manifestations encompass memory loss, cognitive impairment, personality changes, and in severe cases, hallucinations and seizures (74)