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Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease

In the case of LSEC zonation, we did not detect significant differential expression of LSEC markers or gene signatures in the EC clusters, indicating that zonation is not yet established in our model

[1] Other manifestations of B12 deficiency include glossitis (sore, red tongue), mouth ulcers, visual disturbances, and in severe cases, psychiatric symptoms such as depression, psychosis, or dementia-like presentations

Wegovy EPAR product information (PDF) European Medicines Agency

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