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2 Reversal is unlikely to be necessary for many other situations, e.g., when bleeding has stopped or can be managed with local measures, or when the procedure can be postponed for at least eight hours to allow the clearance of parts of the DOACs' effect

The corresponding IC50 values for the oxazole derivative 46 with the extended P1 side chain were 35 and 57 nM, respectively (Kokkala et al., 2016)

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The Role of Vitamin B12 Within The Body