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PMID: 4 van de DonkNWCJJanmaatMLMutisTLammerts van BuerenJJAhmadiTSasserAKet al

RNA, protein, and enzymatic evidence In the serum of 30 patients with bipolar depression, oxidant nitric oxide levels were increased while antioxidant SOD levels were decreased compared to healthy controls, suggesting that the ability to cope with oxidative stress is impaired in bipolar depression [83]

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Results: The models explain why women of childbearing age have higher glutathione than men, and that this is caused by the balance of activation of glutamyl cysteine synthetase (GCL) and glutathione peroxidase (GPX) by estradiol