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By the negative crosstalk between WNT and PPAR, lithium administration, by inhibiting the GSK-3 could act as a PPAR antagonist and lead to an increase in the WNT pathway, resulting in diminution of oxidative stress

In this context, female rats with completely sterile IGF-1R knockout had no antral follicles and exhibited a decrease up to 90% in the serum E2 level [27]

Veldhuis JD, Patrie JM, Frick K, et al

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

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