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"We cannot recommend peptide therapies that lack regulatory approval and adequate clinical trial evidence," stated the AACE 2023 obesity guideline update, which specifically addressed the proliferation of unapproved compounded peptides for weight management [9]

A deficiency or lack of Vitamin B12 is quite common in the over 65s, those diagnosed with pernicious anaemia, and in anyone who follows a vegan, strict vegetarian, or extreme/fad/restricted diet for a long time without taking a B12 supplement or eating fortified foods

No adverse interaction between the two is documented in the research literature