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These mechanisms do not operate in isolation but rather form a self-amplifying vicious cycle: mitochondrial damage exacerbates OS and promotes pathological -syn aggregation

Hypoxia-inducible transcription factors (HIFs) induce the expression of glycolytic enzymes, glucose transporters, lactate exporters, and pH regulators

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

At 100+ pounds of loss, the skin has been dramatically stretched for years and the damage to collagen and elastin networks is more extensive