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The reversible reaction i.e., deglutathionylation, occurs either by the intervention of Grxs or by direct thiol/disulfide exchange reactions with GSH once an appropriate GSH/GSSG ratio has been restored

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NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimers disease astrocytes