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Mitochondrial fusion is necessary to repair cell damage, form networks, and exchange genetic information [311]

Nat Chem Biol 287(15):1236512378 Barthelme D, Scheele U, Dinkelaker S, Janoschka A, Macmillan F, Albers SV, Driessen AJ, Stagni MS, Bill E, Meyer-Klaucke W, Schnemann V, Tamp R (2007) Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1

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The clinical consequence ranges from local inflammation through to systemic hypersensitivity and antibody formation

Published studies in rodent models have documented effects on tendon-to-bone healing, ligament recovery, muscle crush injury recovery, and gastrointestinal mucosal integrity