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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

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PMID: 18954709

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If you fish around the internet enough, you will find some anecdotal claims of insomnia and restlessness linked to excessive B12 intake, but direct causality has yet to be analyzed by experts