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Furthermore, the quantity and function of mitochondria can directly determine the oxidative phosphorylation efficiency of the skeletal muscle (143)

[PubMed: 29563157] 109

Whether this dose should be maintained for long-term treatment is currently being investigated in the BOND study, which evaluates the effects of 12 months of benfotiamine treatment (300 mg twice daily) on morphometric, neurophysiological and clinical parameters in individuals with T2D and mild-to-moderate symptomatic DPN [73]