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Cell Stress Chaperones (2015) 20:10920

Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway

METALLURGY C07ORGANIC CHEMISTRY C07DHETEROCYCLIC COMPOUNDS C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links CCHEMISTRY

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One such acid-inducible gene encodes isocitrate lyase that converts isocitrate to succinate and glyoxylate ( + to make isonicotinoyl-NAD that inhibits mycolic acid synthesis, a bacterial cell wall component, subsequently interfering with mycobacterial cell wall integrity ( rpoB that encodes RNA polymerase B protein ( Figure 1 )