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8 Toxicity and side effects The toxicological problems associated with herbal medicines are a major public health issue

The study protocol was approved by the ethics committee of Louisiana State Health Sciences Center-Animal Care Committee (Animal Care protocol number P-15-006), and all the methods were carried out following the approved guidelines

The quaternary N-methylated quinoline ring with a 5-amino group enables selective recognition by the NNMT active site, where it acts as a competitive inhibitor