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Radiation combined injury: DNA damage, apoptosis, and autophagy

Laura M, Yasmina E HS, Patrick T W, Padraic G F

The antioxidant and anti-inflammatory effects of NAC [23,24,25,26,27] may be downstream consequences of inhibition of NAC-induced nuclear factor-B-activated pathways that include cytokine cascades and phospholipid metabolism [28], which may also underlie the broader efficacy of NAC in rodent ischemia-reperfusion cerebral stroke models [24, 27, 29], a rodent sensory nerve axotomy model, and prevention of mitochondrial damage with loss of dendritic spines in hippocampal neurons [30]

Gel electrophoresis experiments involved treating cells in an identical manner to those used for the image analysis presented in Fig

Clin Cancer Res (2014) 20(12):30717