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In the Phase II WILLOW trial (NCT05162586), enpatoran demonstrated a significant dose-dependent reduction in cutaneous disease activity among patients with CLE or mild SLE and active skin involvement (CLASI-A8), achieving the primary endpoint at Week 16 ( p =0.0002)

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The primary antidotes are fomepizole and ethanol (as a competitive inhibitor), both of which block the enzyme alcohol dehydrogenase, preventing toxic metabolite formation