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The exception worth mentioning is that very high-dose folic acid can mask vitamin B12 deficiency on laboratory testing (by correcting macrocytic anaemia even if B12 itself remains low)

Therefore, further characterization of the polyubiquitin chains and identification of the modified residues in Chac1 might give new insights into understanding the post-translational regulation of Chac1

Consistent with the findings from germline knockout models, AAV-mediated GPR146 depletion significantly reduced hepatic triglyceride content and suppressed the expression of key inflammatory markers in the liver (Fig