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Oxidative damage to DNA in patients with cystic fibrosis

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21,27 In conclusion, iron is one of the most crucial metal elements in all organisms and maintaining iron homeostasis is essential for regulating the uptake of iron, preserving normal physiological activity, and ensuring proper organ function in the body

Indeed, chronic ROS can cause protein oxidation of methionine and cysteine residues 112,113 , which in the absence of GSH becomes permanent and might decrease irreversibly CI and CII functionality

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