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The livers detoxification pathways are often described in three phases: Phase I: Liver enzymes modify compounds, preparing them for further processing

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This thwarts the absorption of these chemicals into the presynaptic terminal [27] and allows a large concentration of dopamine, serotonin and norepinephrine to build up in the synaptic cleft

although WCV treatment reduced Col1a1 close to that of the control in the VM group, PD-1 antibody treatment did not have any rescue effects in the PM group (Fig