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PubMed Research demonstrates that azelaic acid-nicotinamide cocrystal architecture achieved a 9.6-fold enhancement in aqueous solubility and enhanced PPAR- binding capacity

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Note that the co-existence of IBD and PSC is a distinct phenotype that differs from IBD alone [212] and that IBD within IBD-PSC is usually less severe than IBD alone, which could explain why IBD-PSC patients have a good response to mesalamine (a first-line drug for ulcerative colitis) for their IBD, when IBD is not too advanced [212]

Acta Vitaminology and Enzymology 4: 135-140.Google Scholar DE SIMONE, C., FAMULARO, G., TZANTZOGLOU, S., TRINCHIERI, V., MORETTI, S