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Dysfunction of the intestinal epithelial barrier and increased permeability results in a leaky gut that is associated with intestinal disorders such as inflammatory bowel disease (IBD), bowel syndrome irritable liver disease (ILD), alcoholic liver disease, nonalcoholic fatty liver disease, steatohepatitis, liver cirrhosis, and collagen diseases (Figure 2)

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Journal of Biological Chemistry 281, 24756-24768CrossRefGoogle ScholarPubMed 25Dinkova-Kostova, A.T., Holtzclaw, W.D., Cole, R.N