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Then, at last years conference, he met Lee

If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.47912 The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency

Am.J Clin.Nutr 1975;28(5):465-470

CAUSES OF FOLATE DEFICIENCY a In severely folate-deficient patients with causes other than those listed under Dietary, poor dietary intake is often present