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Intestinal Permeability and Hypertension: The Chicken and Egg Question A key question that remains is if hypertension leads to increased internal permeability, or if intestinal permeability, caused by other factors such as low fibre intake, gut dysbiosis, medication or comorbidities such as obesity, activates inflammatory processes that contribute to the development of hypertension

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However, many people with fatty liver have other risk factorssuch as metformin use, proton pump inhibitors, or dietary restrictionsthat can independently lead to B12 deficiency, making monitoring important when symptoms or risk factors are present