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Once the pathogenic trigger has been treated or removed, chronic disease persists because healing is incomplete. Robert Naviaux, MD, PhD In this model, each chronic illness results from abnormal persistence of the normal phase of the healing cycle

Kamrun Nahar is grateful to the Japan Government Ministry of Education, Culture, Sports, Science, and Technology (MEXT) for financial support

Indicator tests with carbon tetrachloride Species Strain Measured end-point Test conditions Activation a Inducation b Results c Reference Bacterial systems Escherichia coli WP2 (repair DNA repair variation 1: liquid - + De Flora et al., proficient WP67 micro method 1984 (uvrA polA-) CM871 (uvrAa, + rat PCB + recA-, lexA-) variation 2: 24 h - + preincubation and plating out + rat PCB - In vitro mammalian cells Chinese hamster ovary cells SCE concentration: 0.001, - + d Athanasiou & 0.1, 1 mM

B., Zaidi, A