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Additionally, notoginsenoside R1 has been reported to improve microvascular endothelial function in animal models of hypertension, partly by reducing inflammation (e.g., lowering VCAM-1 expression as noted earlier)

The bloodbrain barrier tightly regulates brain extracellular composition of glutamine, glutamate and GABA irrespective of the level in the blood (Reference Hawkins and Vina46,Reference Dolgodilina, Imobersteg and Laczko47)

Compared to the contralateral side, bone loss significantly increased on the ligature side in both groups, whereas values measured on the contralateral sides were not significantly different between the two groups ( Fig