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3.2 The pathogenesis of diabetic cataract In diabetic patients, prolonged hyperglycemia leads to excessive accumulation of sorbitol in the lens, increased osmotic pressure, influx of aqueous humor, leading to intracellular edema and fiber breakage, ultimately leading to lens turbidity and further worsening the extent of oxidative stress

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Collectively, these findings indicated the tolerance to self p53-derived peptides in vivo , likely resulting from their significantly decreased surface presentation by normal tissues, and established the ability of p53-specific CTLs to selectively eliminate p53-overexpressing tumor cells, highlighting both mutant and wild-type p53 epitopes as attractive tumor-associated antigens for immunotherapeutic strategies ( Figure 4 )

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