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Hamdy SA, Hatem S, Elosaily H, Hassan AGA-E, Elshimy R, Osman AH, et al

Financial support was provided by FRISBI (ANR-10-INBS-0005 to C.B.), Instruct-ERIC (PID 15107 to K.V.), iNext-Discovery (project number 17947 to K.V

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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful