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No controlled human study has established a beneficial NAD effect or its clinical significance

If you suffer from vitamin B12 deficiency, you may notice that you are losing muscle strength or mass

Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability

This varies by tier and individual response

Some of the most common symptoms of vitamin B12 deficiency are fatigue, memory issues, insomnia, stomach issues, etc