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The Hypoxia-Inducible Factor (HIF) pathway, activated under low oxygen tension (hypoxia), also exerts profound influence on redox balance

Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock: the ACTS randomized clinical trial

Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

For example, inhibiting the key enzyme kynurenine 3-monooxygenase(KMO) promotes the metabolic flux toward the neuroprotective kynurenic acid(KYNA), which effectively alleviates neuropathic pain and its accompanying depressive-like behavior in preclinical models