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Similar to IBA57 and YgfZ, the activity of COG0354p and COG0354m is folate-dependent (Waller et al., 2012)

The complete reaction can be represented as: GR helps to regulate the GSH/GSSG ratio and supplies GSH to guaiacol peroxidase (GPX) and dehydroascorbate reductase (DHAR)

Aquaporin 5 (AQP5) is elevated in NSCLC, and may potentially influence intracellular swelling and interconnect with other signaling pathways, as shown in Figure 5