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A total of 13 RCTs (Buele et al., 2024

Anti-tumour necrosis factor therapy for ulcerative colitis: evidence to date

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During this process, dsRNA as a direct and potent ligand for NLRP6 promotes the LLPS of oligomerized NLRP6, leading to the formation of condensation, which increases the local concentration of the pyrin domain (PYD), facilitating filamentous PYD-PYD interactions that recruit ASC