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DPP1 inhibitors reduce mucus production by alleviating inflammatory responses, while mucolytic agents primarily improve clearance efficiency of already produced mucus (Yang et al., 2019)

Additionally, no new nanomedicines have been approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA) for RA between 2023 and 2025, highlighting significant gaps in translating laboratory innovations into clinical practice (54)

Fatty acyl-CoA is then metabolized through -oxidation in the mitochondrial matrix, ultimately yielding propionyl-CoA and acetyl-CoA (6)

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The dosage is titrated every 4 weeks