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Contrary to these results, it was demonstrated that mutations IDH1 R132H or IDH2 R172K in MEF and HeLa cells induce an increase in 2HG levels that stimulate both mTORC1 and mTORC2 signaling as highlighted by enhanced phosphorylation of p70S6K, pS6 and Rictor, and Akt, respectively

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doi: 10.3390/foods9111606 121 Duda-ChodakATarkoT

It is estimated that approximately 6% of men report non-medical testosterone use ( Studies conducted among strength athletes and bodybuilders have consistently demonstrated high rates of anabolicandrogenic substance use

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