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Pathological progression induced by the frontotemporal dementia-associated R406W TAU mutation in patient-derived IPSCs

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Similarly, glutathione peroxidase 4 (GPX4), an essential mitochondrial antioxidant enzyme protecting cells from lipid peroxidation and ferroptosis [126], and nuclear factor erythroid 2-related factor 2 (NFE2L2), which governs the oxidative stress response and mitochondrial homeostasis [127, 128], initially increase but then markedly decrease in later disease stages [115]

In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]

Be sure to use kid colostrum replacer (not calf colostrum and not regular milk replacer)