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Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, et al

Additionally, we reassessed the relationships between prefrontal GABA and CBF levels within the PTSD group after excluding potentially influential data points, further confirming the stability of the original findings

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The conservative cutoff is the labeled date

Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024