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Firstly, MNAM is unstable in vivo

through whole exome sequencing and transcriptional profiling of cetuximab-resistant colorectal tumors

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Caster J., Patel A.N., Zhang T., Wang A

This extended longevity might be triggered by the activation of alternative CYPs which contributes to longevity through the clearance of toxins generated by endogenous processes, such as metabolism as well as lipophilic by-products (Gems and McElwee 2005)