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Thomas AM, Atkinson TJ

Triterpenoids are common type compounds in natural products, so far, some of triterpenoids have been reported from Celastrus orbiculatus , Azadirachta indica, and Codonopsis lanceolata

Within the cereblon-based PROTACs, the best ones were those with azacyclic linkers (such as piperazine, piperidine, pyrrolidine, and azetidine) instead of flexible linkers 106

The dysregulation of lipid metabolism is now known as one of the key drivers of oncogenic processes, a metabolic phenotype shown to promote cancer development and therapeutic resistance in various cancers, including CRC (66)

In a study conducted by Zenk (1971), it was concluded that phenylalanine is initially transformed into cinnamic acid via the phenylpropanoid pathway, facilitated by the enzyme phenylalanine ammonia-lyase (PAL)