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Fluoride being beneficial at minimal concentrations was used for dental caries prevention, but excessive exposure of fluoride has been associated with numerous health disorders including skeletal and dental fluorosis, weakening of bones making them more prone to fractures, impaired intelligence, stunted growth, reduced birth and fertility rates, and disruption of thyroid function

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Description 5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes NAD+ precursors and is reported to be elevated in aged adipose tissue, obese skeletal muscle, and certain tumor types

Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals to evaluate carcinogenic potential have not been done