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Metformin and resveratrol have been shown to reduce the development of hypoxia-inducible factor (HIF)-1 inflammation and fibrosis in mice fed a high fat diet (139)

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AmentaVAschbergerKArenaMBouwmeesterHMonizFBBrandhoffPet al

doi: 10.1007/s00198-026-07861-6

Long-term aerobic glycolysis can uncouple enzymes of normal OXPHOS, causing a chronic Warburg effect and accumulation of intracellular fatty acids, nucleotides, amino acids, and, through the activation of the polyol-mechanism, sorbitol and sorbitol-attracted water (Singh et al., 2021