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malabsorption (insufficient absorption of vitamin B12 in the intestine), insufficient production of intrinsic factor (a protein that is formed in the stomach lining and required to absorb vitamin B12), Diseases in the end section of the ileum (part of the small intestine), e.g

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The Cleveland Clinic notes that IV nutrient therapy may be appropriate in select clinical contexts when oral intake is limited or absorption is impaired

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Mohammad Ebrahim Ghaffari for his guidance and invaluable consultations on the statistical analysis of this work