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Causes The exact cause of coeliac disease is not fully understood as it involves a complex interaction between genes and environmental factors

52 Thus, S6K and 4E-BP1 were named canonical (nonlysosomal, RHEB-TSC-dependent), whereas TFEB/TFE3 are noncanonical (lysosomal, RHEB-TSC-independent) mTORC1 substrates