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Taken together, PNPLA2-mediated intracellular lipolysis promotes crosstalk between cancer cells and adipocytes and subsequently promotes tumor progression and aggressiveness

Because of its ability to increase intestinal permeability, functional screening of Zot protein was conducted, leading to the discovery of a human intestinal Zot analogue, zonulin, which, like Zot, has been shown to reduce TEER of intestinal tissue (7)

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